"Queen" Sandra is a Maniac in Dead Rising 4. She is a woman dressed in a suit of armor who lurks in the medieval town section of the mall, along with several other "knights". Her weapon is a Flaming Sword.
She is the first maniac in the game, and the only one required to fight in order to progress with the story.
Frank West encounters Sandra when he must return inside the mall. The gate is closed and guarded by her followers, and they taunt Frank, intending to steer him off. However, Frank manages to get under their skin as well, and they open it. Afterwards, Frank must fight through the knights before getting to Sandra herself.
Credit to Xbox Live user GOSEIRED for high quality screenshot.