- "The human race deserves the zombie apocalypse, and now look at you. You destroy the very company that brings you the medicine to heal your loved ones."
- —Marian Mallon, to Frank West and Chuck Greene
Marian Mallon is the main antagonist of Dead Rising 2: Case West. She a wheelchair-bound woman who works for The Phenotrans Corporation, and serves as the director for the Phenotrans Facility. In the game credits, she is referenced as "The Director," but it isn't clear if she's the director of Phenotrans itself, or just the facility. (There's an image in the gallery that says that she is the Director of the facility)
Marian Mallon has a zombie bite-mark on her left cheek, which has seemingly never healed. She claims that her infection is irrelevant, in that she doesn't need Zombrex anymore as she was cured by an actual antidote for the parasite. Whether this is true or just a bluff remains to be seen. Most of her background is shrouded in mystery, with only a few small tokens of her life found in the Director's Office.
She exhibits an extreme misanthropic personality, stating that since the greed of humanity is what created the zombie plague in the first place (referring to the research behind Santa Cabeza, which was intended to double the livestock of cattle). As such, the human race deserved the zombie apocalypse.
Ms. Mallon isn't encountered until practically the end of the story. When she finally reveals herself, she orders her security guards to take Isabela Keyes hostage, and then sets her security chief, Harjit Singh upon Frank West and Chuck Greene. After Mr. Singh is defeated, Ms. Mallon ridicules the Frank and Chuck for their needless meddling in Phenotrans' affairs, and then initiates the facility's self-destruct sequence. Before departing with an unconscious Isabela, she ominously remarks: "There will need to be another harvest now, you reap what you sow."
- She is the only main antagonist of the Dead Rising series who survives the respective game's events, and so far the only one that the player does not battle.
- Marian is very similar to Ozwell E Spencer of Resident Evil as both are high ranking members of an antagonistic pharmecutical company, were wheelchair-bound as a result of serious illnesses, and both possess deep misanthropic natures regarding humanity.
- Her name could be a possible reference to Mary Mallon, better known as Typhoid Mary, a cook who was identified as the first healthy carrier of typhoid fever.
- One portrait in her director's office is of her face, with her scars. There is another portrait of a woman's face as well, who is quite beautiful. It is possible that this is a picture of her before receiving her scars, as there is no other reasonable explanation for why it is there.
- She is apparently a fan of Bibi Love, as Marian has a portrait in her office of Bibi Love performing on stage in her leather outfit. This portrait seems to be signed "Bibi" or "Diva", and also near the middle of the picture there seems to be an inserted square picture of someone's face, possibly Marian's.
- Two pictures of newspaper clippings are framed in her office.
- The first newspaper clipping is the front page of the November 2004 issue of Modern Research. The headline states "Esteemed Doctor Awarded Monroe Medal" with a subtitle of "Leading bionitics doctor overcomes brutal infected attack and goes on to lead biogenetic field". Unknown if this November 2004 newspaper clipping references was the zombie attack that scarred her face, as it wasn't until September 2006 that the Willamette Incident took place to spread the zombie virus. It may be possible that she was present during the Santa Cabeza incident.
- The second newspaper clipping is the front page of November 2009 issue of Biotech Newswatch. The headline states "Leading bionetics doctor to become director of new research facility" with subtitle of "Pure research center will drive future innovations of Phenotrans products and profits".
- Although not confirmed or denied, Marian's last remark that there will be "another harvest" could mean that the new setting for Dead Rising 3, Los Perdidos, suffered an outbreak ON PURPOSE by Phenotrans.