Esther is found in Children's Castle in the Royal Flush Plaza, trying to buy a toy for her grandchild. When Chuck Greene approaches her, she mistakes him for a store employee and complains about the customer service. Chuck tells her that there are zombies outside the store, but she misunderstands him, and says that her grandchild is much too young for zombie toys. Once Chuck convinces her that the zombies are real, she agrees to follow Chuck to the Safe House.
Before joining, she claims that her bunions keep her from moving too fast, therefore she must be carried.
During Stuart's mutiny, Esther is convinced that Chuck is the man responsible for the outbreak. If Chuck does not stop the mutiny in time, Esther will leave the safe house along with Stuart and several other survivors, and will never be seen again in that playthrough.
Depending on the ending, Esther was either rescued by a helicopter sent by the Channel 6 News Station, killed by the military firebombing, or killed by the military rescue squad to cover up the truth behind the outbreak.